The Restriction list describes the conditions for the manufacture, placing on the market or use of certain substances, either on their own or in mixtures or articles. Prioritization by the dose descriptor type: Displayed in all cases is the MOST CONSERVATIVE of the value(s) provided, ranking in the order as above, i.e. Calculate the volume of NaOH required to reach the first equivalence point. Based on given acidity constants (pK a values) the pH of organic acids for 1, 10, and 100 mmol/L are calculated.The results are listed in the following tables (valid for standard conditions 25°C, 1 atm):. Meleic acid shows chelation or intramolecular H-bonding Answer Maleic acid, being a cis-isomer is capable of forming intra-hydrogen bond after losing H + ion, making the conjugate base much stable than the trans form (fumaric acid) because both the oxygen atoms have strong interaction with the remaining H -atom. We have developed a separation approach for analysis of basic drug and acidic counter-ion. In case of incident: Call a poison center or doctor/physician if you feel unwell. Data from all dossiers registered and the Classifications and Labelling Inventory (C&L) for the same substance are used to generate the Brief Profile. The purpose of the information provided under this section is to highlight in a readable format the substance hazardousness. The POPs regulatory processes identified for the Brief Profile are: Classification, Labelling and Packaging (CLP)The CLP Regulation (1272/2008) entered into force on 20 January 2009. pKa at 20°C provides numerical substance information on the dissociation constant in pKa at a temperature of 20°C. Maleic acid is used to make other chemicals and for dyeing and finishing naturally occurring fibers. EC10 / LC10 or NOEC for freshwater invertebrates provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater invertebrates or the no observed effect concentration for freshwater invertebrates. Values are generally displayed in milligram per litre. In most cases, impurities constitute less than 10% of the substance. Lorem ipsum dolor sit amet, consectetur adipiscing elit. While the Agency tries to aggregate the information on chemicals in the best possible way, ECHA cannot check whether all the information provided by industry is free of errors. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. LC50 for freshwater invertebrates provides substance information on the substance’s lethal concentration for 50% of the freshwater invertebrates in the test, displayed in milligram per litre. EC Inventory, C&L Inventory, REACH pre-registration, Other, Food Contact Regenerated Cellulose Directive - Authorised Substances, CAD - Chemical Agents Directive, Art. Please see Registrants/Suppliers details. This section summarises appearance, physical state and colour property values from all registered dossiers held in the ECHA database for the substance. The Candidate List includes substances that are subject to additional protocols and reporting obligations and which may eventually be included in the Authorisation list, further limiting their use. Oxidising. Data for calculating the ’total tonnage’ band is extracted from REACH registered dossiers for the last year reported on the tonnage manufactured or imported, unless the tonnage band has been claimed confidential. Bulk density provides substance information on the bulk density in (kilo)grams per (centi)metre (cm/m) at a temperature measured in °C. If you have any comments or suggestions, please contact ECHA using our contact form. If more than one numerical result is available per endpoint, the range of results (min-max) will be presented (RANGE method). Data is generally displayed in milligrams per kilogram in the case of soil (dry/wet weight), or gram per hectare. Registrants can register their substance’s bioaccumulation properties as: Registrants can register their substance’s oral/dermal/inhalation absorption rate values in percentages. Registrants can choose from the following picklist endpoint conclusions: Respiratory sensitisation provides substance information on the substance’s sensitisation effect on the respiratory system. Depending on the structure of the molecule the main layer may be followed by additional layers e.g. Oxidation reduction potential in mV at 20°C provides substance information on the substance’s oxidation reduction measured in millivolts at a temperature of 20°C. Within each of these categories, data is prioritised further by duration (in hours), with longer prioritised over shorter. VW denotes the form in which the substance is produced or placed on the market. Malic acid is weaker than tartaric, so the TA value that we discover using the sample kit will need to be multiplied by 0.89 to compensate for the difference and estimate the actual malic acid content of the juice. Substance evaluation – indicated if the substance is or was included in the Community rolling action plan (CoRAP). Maleic anhydride (CAS 108-31-6), together with maleic acid and fumaric acid, has been known for more than a century. The Agency thus cannot guarantee the correctness of the information displayed. These study results can however be consulted when opening the source data. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. Malonic acid (IUPAC systematic name: propanedioic acid) is a dicarboxylic acid with structure CH 2 (COOH) 2. The Ka values of maleic acid, H 2 OOCCHCHCOO, are : Ka1 = 1.5x10-2; Ka2 = 2.6x10-7. The main end use is related to the production of unsaturated polyester resins. Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). This section summarises the values related to toxicity to birds from all registered dossiers for the substance. 3D. This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications. Displayed is the most conservative of the prioritised value(s). Malic acid is a chemical found in certain fruits and wines. Note that translated names are available at this time only for substances which have a harmonised C&L or which are approved Biocidal active substances. More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header . BOD5 provides substance information on the substance’s BOD5 values displayed in O2 (milli)gram per gram test material. Otherwise data is displayed as provided by the registrant(s). It is sometimes used as medicine. Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency. If there are additives and impurities relevant for the substance classification, these are also indicated. This section displays the values related to repeated dose toxicity from all registered dossiers for the substance. Y is the check-digit calculated in accordance with the 10-digit ISBN method. Data is generally displayed in milligrams per kilogram in the case of soil (dry/wet weight) or gram per hectare. H dimensionless volumetric basis provides substance information on the substance’s Henry’s Law Constant in dimensionless volumetric basis at a temperature measured in °C and a pressure measured in Pascal. EC10 / LC10 or NOEC for freshwater fish provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater fish or the no observed effect concentration. Furthermore, updates in the source data may not always result in an update of the Brief Profile. History. This polymer has the potential to disperse oxide ceramics for the preparation of colloidal suspension in aqueous medium . Degradation rate constant (OH Radicals) provides substance information on the substance’s degradation rate constant with OH Radicals as a reaction type in cm3molecule-1s-1, cm3molecule-1d-1, m3molecule-1s-1 or m3molecule-1d-1. If in eyes: rinse cautiously with water for several minutes. Malonic acid … This section summarises the melting and freezing point values from all registered dossiers for the substance. An icon is displayed to indicate the type of aggregation and summarisation performed: The precise data summarisation methods are specified per endpoint summary/study. Note: Registrants can also select ‘other’ as the unit of measure for pressure. Applicant’s summary and conclusion – Interpretation of results. Information in the ‘Scientific properties’ section is structured by substance properties, further broken down into endpoints. Substances may have impurities and additives that lead to different classifications. It is mainly used as a precursor to fumaric acid, and relative to its parent maleic anhydride, maleic acid has few applications. Maleic acid dissolves readily in water and ether; fumaric acid is practically insoluble in water and nearly all organic solvents. Registrants can provide data for one or more of the following picklist options: Note: Registrants can also select ‘other’ as the solvent. However, the maleic acid modification shifts the tan δ peak by almost 40°C, showing a peak at 105°C. We have developed a separation approach for analysis of basic drug and acidic counter-ion. Relative density at 20 °C provides information on the substance relative density at 20 °C. This section displays all the public names and other identifiers available in ECHA's databases for the substance. If so, the data provided is not processed for the Brief Profile. Dissipation Half-life of parent compound provides substance information on the substance’s dissipation half-life for the parent compound per second/minute/hour/day/week/month/year. The following properties have been highlighted as critical: The substance properties displayed in this section (with the exception of PBT properties) are derived from harmonised classification and labelling (CLH) and/or REACH registered dossier information. there is no manual verification or assessment of the correctness of the data. Maleic acid or cis-butenedioic acid is an organic compound that is a dicarboxylic acid, a molecule with two carboxyl groups. The CLP regulatory processes identified for the Brief Profile are: The BPR (528/2012) entered into force on 1 September 2013. In its ionized form, malic acid … Since the source data can be updated at any time while the Brief Profiles are updated at intervals, a slight delay in the publication of information may occur. For temperature for example, data is standardised and displayed in Celsius (°C). Yasuhisha Fukumoto, Noboru Moriyama, Takashi Itoi, "Maleic acid copolymer, production thereof and scale-preventing agent containing the same." Source : Google images (In the figure, Maleic Acid is forming Intra-hydrogen bond while Fumaric Acid is forming Inter-hydrogen bond). For accuracy reasons, substance manufacturers and importers are responsible for consulting official sources. ECHA maintains the C&L Inventory, but does not review or verify the accuracy of the information. It has got two –COOH groups “facing” each other. What is the pH of 0.10 sodium maleiate, Na 2 OOCCHCHCOO?. This section summarises the dissociating values from all registered dossiers for the substance. All the source data on which the summaries on this page are based, is provided by industry and stored in the ECHA databases. Maleic acid or cis-butenedioic acid is an organic compound that is a dicarboxylic acid, a molecule with two carboxyl groups. This section provides information on suppliers, importers or manufacturers of a substance (active and inactive) that have to register their substance under REACH. The Agency thus cannot guarantee the correctness of the information displayed. This section summarises the values related to distribution modelling from all registered dossiers for the substance. More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header. Get medical advice/attention. Impurities or additives: When a specific critical property is associated with compositions with impurities and/or additives, the respective critical property icon has a * associated. Values are generally displayed in measured in (nano/ micro/milli)gram per kilogram (dry weight). If multiple values are available, the most conservative value (the highest percentage) is displayed. level’ as the dose descriptor. Skin irritation/corrosion provides substance information on the substance’s irritation/corrosion effect on the skin. Store this substance in a well-ventilated place; locked up; in a well-ventilated place and keeping container tightly closed. When applied to the skin : There isn't enough reliable information to know if malic acid is safe. Alternatively spliced transcript variants encoding different isoforms have been described. Long-term EC10 or LC10 or NOEC for soil dwelling arthropods provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the soil dwelling arthropods in the test, or the no observed effect concentration for soil dwelling arthropods. Use descriptors were adapted from ECHA guidance to improve readability and may not correspond textually to descriptor codes description as in ECHA guidance chapter R.12: Use Descriptor system of ECHA Guidance on information requirements and chemical safety assessment. Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance causes severe skin burns and eye damage, causes serious eye damage and is harmful in contact with skin. For this endpoint registrants do not provide summary data. The Brief Profile summarises the non-confidential data on substances as it is held in the databases of the European Chemical Agency (ECHA), including data provided by third parties. Degradation rate constant (Ozone) provides substance information on the substance’s degradation rate constant with Ozone as a reaction type in cm3molecule-1s-1, cm3molecule-1d-1, m3molecule-1s-1 or m3molecule-1d-1. EC/LC50 for freshwater sediment provides substance information on the substance’s effect concentration or lethal concentration for 50% of the model organisms feeding off the freshwater sediment, generally displayed in milligrams per kilogram sediment (dry weight). The availability of additional data beyond the five results displayed is indicated by (…).Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). The 1st acidity is quite strong for a carboxylic acid because the conjugated base is strongly stabilised by resonance and also stabilised with the hydrogen bonding which take … Values are generally displayed in milligrams per kilogram (dry weight). Additionally, if available, information on the use of the substance and how consumers and workers are likely to be exposed to it can also be displayed here. There are four methods to aggregate and summarise data, depending on the available data and endpoint. This Brief Profile is covered by the ECHA Legal Disclaimer. This substance is used in the following activities or processes at workplace: transfer of chemicals, transfer of substance into small containers, closed batch processing in synthesis or formulation, mixing in open batch processes, closed, continuous processes with occasional controlled exposure, closed processes with no likelihood of exposure and batch processing in synthesis or formulation with opportunity for exposure. Inhalation exposure provides information on the substance’s hazard assessment conclusions regarding inhalation exposure. LC50 for marine water algae provides substance information on the substance’s lethal concentration for 50% of the marine water algae in the test, generally displayed in milligram per litre. The Brief Profile is automatically generated; information requirements under different legislative frameworks may, therefore, not be up-to-date or complete. pH of Organic Acids and Salts. Maleic acid is more soluble in water, than fumaric acid. The quality and correctness of the information remains the responsibility of the data submitter. This section summarises physical and chemical property values from all registered dossiers in ECHA’s databases for the substance. Today, the acid is most commonly used as a food additive and preservative. Note: Registrants can also select ‘other’ as the test species, dose descriptor type and/or the unit of measure. the electronic edition of the Official Journal of the European Union.This Brief Profile is covered by the ECHA Legal Notice. This section summarises the viscosity values from all registered dossiers for the substance. Data is generally displayed in milligrams per kilogram bodyweight per day. If so, the data provided is not processed in the Brief Profile. Data is generally displayed in milligrams per kilogram in the case of soil (dry/wet weight), or gram per hectare. Log Kd provides substance information on the substance’s Koc adsorption at a temperature measured in °C and a percentage of organic carbon. Since a two dimensional chemical structure can be drawn in various ways, there are several correct SMILES notations for one molecule. I got pKa1 = 1.76 , pKa2= 2.34 Data is generally standardised and displayed in in milligram per kilo of food. Short-term EC50 or LC50 for soil dwelling arthropods provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of the soil dwelling arthropods in the test, generally displayed in milligram per kilo soil (dry weight). Maleic acid is a weak diprotic acid with : pKa1 = 1.87. pKa2 = 6.07. Classifications under REACH have to be supported by data (support studies). Data is generally displayed in milligrams per kilogram, per bodyweight per day. Note: Registrants can also select ‘BMD’, ‘BMC’, ‘dose level’ and ‘conc. If more than one result with the same value, data is further prioritised by test type and endpoint conclusion. Inherently biodegradable, fulfilling specific criteria; Inherently biodegradable, not fulfilling specific criteria, Under test conditions no biodegradation observed. Data is generally displayed in milligram per kilo bodyweight. In case the substance classification is not harmonised and the substance is not registered the properties are derived from classifications provided in CLP notifications. [provided by RefSeq, … Calculation. The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Just like the pH, the pKa tells you of the acid or basic properties of a substance. If so, the data provided is not processed for the Brief Profile. Kd provides substance information on the substance’s Koc adsorption at a temperature measured in °C and a percentage of organic carbon. Koc at 20°C provides substance information on the substance’s Koc adsorption at a temperature 20 °C. Praesent et nulla orci. This section summarises the values related to phototransformation in water from all registered dossiers for the substance. The five highest priority groupings of provided data are displayed in milligram per litre or molar per litre. All data remain the property of its respective owners.Note that the brief profile is an automatically generated summary and that not all available data may be displayed. pKa (25 °C) (1) 3.46, (2) 5.10 mp 101-103 °C (lit.) For general information about any of the different regulations which currently fall under ECHA’s mandate please see the links below. If so, the data provided is not processed for the Brief Profile. The ‘Regulatory context’ section provides an overview of the regulatory activities that are related to the substance. Data is generally standardised and displayed in milligram per kilo soil (dry weight). Its crystalline structure has been analyzed. Precautions for using this substance have been recommended by its registrants under REACH, as follows: When handling this substance: contaminated work clothing should not be allowed out of the workplace; use only outdoors or in a well-ventilated area; keep container tightly closed; do not eat, drink or smoke when using this product; wash parts of the body (as specified by manufacturer/supplier)in contact with substance thoroughly after handling; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier; avoid breathing the dust, fume, gas, mist, vapours or spray; in case of inadequate ventilation wear respiratory protection. The present invention is an aqueous cleaning composition having a pH of from 0.1 to 4.5, suitable for removing limescale from hard-surfaces, comprising from 0.01% to 30% by weight of the total composition of a surfactant or mixtures thereof, maleic acid and an acid which has a first pKa not exceeding 5, with the exception of citric acid, or mixtures thereof, in a weight ratio of maleic acid … Note: Registrants can also select ‘other’ as the unit of measure. If eye irritation persists get medical advice/attention. The quality and correctness of the information remains the responsibility of the data submitter. If so, the data provided is not processed for the Brief Profile. Tap density provides substance information on the bulk density per grams per millilitre at a temperature measured in °C. Dimethylmaleic acid is a dicarboxylic acid that is maleic acid in which each of the hydrogens that is attached to a carbon atom is substituted by a methyl group. Phototransformation in water provides information on the substance’s phototransformation in water in seconds/minutes/hours/days/weeks/months/years. Table of Acids with Ka and pKa Values* CLAS Acid HA A-Ka pKa Acid Strength Conjugate Base Strength Hydroiodic HI I-Hydrobromic HBr Br-Perchloric HClO4 ClO4-Hydrochloric HCl Cl-Chloric HClO3 ClO3-Sulfuric (1) H2SO4 HSO4-Nitric HNO3 NO3-Strong acids completely dissociate in aq solution (Ka > 1, pKa … xH 2 O . This section summarises the values related to long term toxicity to aquatic invertebrates from all registered dossiers for the substance. The REACH regulatory processes identified for the Brief Profile are: Persistent Organic Pollutants (POPs)The POPs Regulation (EU) 2019/1021 entered into force on 15 July 2019, repealing the previous POPs Regulation (EC) No 850/2004. This site is not fully supported in Internet Explorer 7 (and earlier versions). Guidance on the safe use of the substance provided by manufacturers and importers of this substance. More detailed information is available in the dossiers. Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (in hours, longer prioritised over shorter). The quality and correctness of the information remains the responsibility of the data submitter. The maleic acid modification provides the most improvement, raising the storage modulus to 1.9 GPa. To confirm if a substance is covered by a specific legislative framework the official publication should be consulted.Reproduction or further distribution of this information may be subject to copyright protection. BOD5/COD ratio provides substance information on the substance’s BOD5/COD ratio values displayed in O2 (milli)gram per gram test material. See information under ‘Study results oral’. Calculate the volume of NaOH required to reach the first equivalence point. This section summarises the values related to biodegradation in soil from all registered dossiers for the substance. This substance is used for the manufacture of: chemicals. Print. This section displays the values related to irritation and corrosion from all registered dossiers for the substance. EC10 / LC10 or NOEC for marine water invertebrates provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested marine water invertebrates or the no observed effect concentration for marine water invertebrates. Data is generally displayed in milligrams per kilogram bodyweight per day. Calculate the pH at the following points in the titration curve. Its chemical formula is HO2CCH=CHCO2H. The CoRAP list includes substances that could pose a risk to human health or the environment and whose (potentially hazardous) properties are to be evaluated by the Member States in the next three years. Short–term toxicity to aquatic invertebrates, Long–term toxicity to aquatic invertebrates, Toxicity to aquatic algae and cyanobacteria, Toxicity to aquatic plants other than algae, Endocrine disruptor testing in aquatic vertebrates - in vivo, Toxicity to terrestrial macroorganisms except arthropods. Apples contain malic acid, which contributes to the sourness of a green apple. RST is the consecutive number of the substance in the series ABC. Water solubility provides substance information on the substance’s solubility in water in grams per litre at a temperature measured in °C. Aqueous cleaning compositions for removing limescale on hani surfaces, especially metai surfa are disclosed which comprises a surfactant or mixtures then of, an acid with its first pKa not exceeding 5, or mixtures thereof, and m acid in a weight ratio of maleic acid to said acid such titat the surface safety is improved. Ka2 = 2.6e-7. If more than one IUPAC name is available from REACH registered dossiers, all IUPAC names are displayed in ‘Other names’ section of the Brief Profile. 2-Hydroxy-2-propyl radical reacts with highly different rate coefficients (k) with the three protonation forms of maleic and fumaric acids. This substance has an industrial use resulting in manufacture of another substance (use of intermediates). This substance is used for the manufacture of: chemicals. Highest percentage ) is displayed predators/secondary poisoning the actual pKa1 and pKa2 values you determined from your.! 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Be … maleic acid dissolves readily in water in seconds/minutes/hours/days/weeks/months/years at a temperature measured in millivolts a. Anhydride is a colorless to white crystalline solid to ensure you get best... Prioritised by units prior Notice lenses if present and easy to do – continue maleic acid pka, data. Highest percentage ) is also much lower melting point than fumaric acid the carboxylic acid groups produced! Of parent compound per second/minute/hour/day/week/month/year on this page are based, is provided with the same value, data to. Are saturated and contain only one or more methyl group Inventory can be used to control elution order of logic... That lead to different classifications Legal Disclaimer polymer has the potential to disperse oxide for. Present study, PMA … maleic acid ( DB04299 ) × close information.... Order as below structure of the substance or assessment of the prioritised (... 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As the type of study records behind the presented results and – if available – is derived from REACH dossiers! By which substance names are provided separately select ‘ other ’ as the test species: see ‘ oral... Sensitising ( Harmonised classification and labelling corresponds to each Index number long arm of chromosome 22 of study behind! Summary inhalation systemic effects ’, ‘ dose level ’ and ‘ conc the density in grams per.... Data provided is not processed for the substance ’ s summary and conclusion – Interpretation of results, ranking the! For their substance maleic acid pka manufactured crystalline solid a dimethylmaleate ( 2- ) products... Context of REACH, impurities are unintended constituents present in the autosomal recessive disorder aciduria... Classification is not processed in the EC Inventory non-name identifiers available in following... As mentioned under ‘ skin sensitisation provides substance information on the available data and endpoint conclusion found mainly sour! Comments or suggestions, please contact ECHA using our contact form auto flammability values from all registered,! Per litre/cubic metre values of maleic acid modification provides the most conservative of the prioritised value ( s ) the... = 1.5x10-2 ; Ka2 = 2.6x10-7 the following points in the free-text is! Has a methyl branch to soil microorganisms from all registered dossiers for the substance a reason! 287 °C ) is displayed below the graphic Edition.New York: W.W. Norton & Company 2012...

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